Glycine → L-Leucine

HRID 628459Notes

Reaction equation

HRID 628459 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4]CNC(=N)N.N[C@H:14](C(O)=O)CC(O)=O.[NH2:22][C@H:23]([C:30]([OH:32])=[O:31])[CH2:24][C:25]1N=CN[CH:26]=1.N[CH2:34]C(O)=O>>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH:3]([CH3:14])[CH3:4].[NH2:22][C@H:23]([C:30]([OH:32])=[O:31])[CH2:24][CH:25]([CH3:34])[CH3:26]

Participants

6

Reactant 4

HCID 750GlycineHCID 5960L-Aspartic AcidHCID 178418600HCID 178418600, compoundHCID 178419078HCID 178419078, compound

Product 2

HCID 6106L-LeucineHCID 6287L-Valine

Procedure

Incubation of C. difficile NCTC 11204 spores with arginine, aspartic acid or histidine with glycine and ST produced large log reductions in CFU/mL of 2.78 (99.8%), 3.06(9.99%) and 3.12 (99.9%) respectively after heat shocking. Valine (with glycine and ST) and leucine (with glycine and ST) produced log reductions in CFU/mL of 1.72 (98.1%) and 1.62 (97.6%) respectively, which were similar to that of glycine and ST alone (1.85 log reduction (98.6%)). All other amino acids tested produced log reductions smaller than that of glycine and sodium taurocholate alone.

Sources & evidence

ORD record
ord-e936289dd84c4770bfb0cb0527f57088
Source dataset
uspto-grants-2016_04
Patent number
US09314028B2

Reaction notes

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