反应详情

A mixture of 3-(4-methoxy-3-methyl-phenyl)-1-methyl-5-trifluoromethyl-1H-pyrazole (described in Reference Preparation example 78) 0.4 g, 47% hydrobromic acid 24 ml and acetic acid 24 ml was stirred with heating under reflux for twelve hours. The solvent was distilled off and to the resulting residues was added ice water 70 ml. The precipitates were filtered and were washed with ice water 70 ml, and then were concentrated under, reduced pressure to give 2-methyl-4-(1-methyl-5-trifluoromethyl-1H-pyrazol-3-yl)-phenol 2 g.

1. temperaturewith heating
2. temperatureunder reflux for twelve hours
3. distillationThe solvent was distilled off and to the resulting residues
4. additionwas added ice water 70 ml
5. filtrationThe precipitates were filtered
6. washwere washed with ice water 70 ml
7. concentrationwere concentrated under, reduced pressure