Hydrazine → 4-butyl-3,5-dimethyl-1H-pyrazole

HRID 628544Notes

Reaction equation

HRID 628544 reaction equation
[CH2:1]([CH:5]([C:9](=O)[CH3:10])[C:6](=O)[CH3:7])[CH2:2][CH2:3][CH3:4].[NH2:12][NH2:13]>C(O)C>[CH2:1]([C:5]1[C:9]([CH3:10])=[N:12][NH:13][C:6]=1[CH3:7])[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 737633-Butylpentane-2,4-dione

Product 1

HCID 129332764-butyl-3,5-dimethyl-1H-pyrazoleYield 102.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

At room temperature, to a mixture of 3-butyl-pentane-2,4-dione 7 g and ethanol 70 ml was added hydrazine one hydrate 3.3 g and the resulting mixture was stirred for twelve hours. The reaction mixture was subjected to a silica gel column chromatography to give 4-butyl-3,5-dimethyl-1H-pyrazole 7 g.

Sources & evidence

ORD record
ord-b936d19030ab41229f494a98cfba8d5a
Source dataset
uspto-grants-2016_04
Patent number
US09314023B2

Reaction notes

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