1-Iodopropane → 2-(Propylthio)nicotinic acid

HRID 62856Notes

Reaction equation

[SH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].I[CH2:12][CH2:13][CH3:14]>>[CH2:12]([S:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[CH2:13][CH3:14]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 178524460HCID 178524460, compound

Product 1

HCID 27745262-(Propylthio)nicotinic acidYield 96%

Procedure

2-Mercapto-nicotinic acid (1 g, 6.4 mmol) and 1-iodopropane were reacted in the same manner as in Step A of Preparation Example 10 to obtain the title compound (1.22 g, 96%).

Sources & evidence

ORD record: ord-8a5ce576a1fe4fb3a194a7f69917d929
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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