反应详情

6-Hydroxy-pyridine-2-carboxylic acid ethyl ester (1.8 g, 10.7 mmol) was dissolved in THF (50 mL), and Lawesson's reagent (2.18 g, 5.35 mmol) was added thereto. The mixture was stirred at room temperature for 24 hours. After the termination of the reaction, the reactant was added with water and then extracted with DCM. The organic layer was separated, dried with MgSO4, concentrated under reduced pressure and then separated by column chromatography to obtain the title compound (1.17 g, 59%).

1. customAfter the termination of the reaction
2. extractionextracted with DCM
3. customThe organic layer was separated
4. dry with materialdried with MgSO4
5. concentrationconcentrated under reduced pressure
6. customseparated by column chromatography