Isopropyl iodide → 3-Isopropylsulfanyl-pyrazine-2-carboxylic acid methyl ester

HRID 62864Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[C:10]([SH:11])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].I[CH:13]([CH3:15])[CH3:14]>>[CH3:1][O:2][C:3]([C:5]1[C:10]([S:11][CH:13]([CH3:15])[CH3:14])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4]

Participants

Reactant 2

HCID 6362Isopropyl iodide

HCID 178499101HCID 178499101, compound

Product 1

HCID 901180683-Isopropylsulfanyl-pyrazine-2-carboxylic acid methyl esterYield 61%

Procedure

3-Mercapto-pyrazine-2-carboxylic acid methyl ester (0.35 g, 2.0 mmol) obtained in Step A and 2-iodopropane were reacted in the same manner as in Step A of Preparation Example 5 to obtain the title compound (0.267 g, 61%).

Sources & evidence

ORD record: ord-9c6637ca917049fabc1a23509cbfe685
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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