2-Propanethiol → 2-Isopropylsulfanyl-6-methoxy-nicotinic acid methyl ester

HRID 62882Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1Cl.[CH3:14][CH:15]([SH:17])[CH3:16]>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1[S:17][CH:15]([CH3:16])[CH3:14]

Participants

Reactant 2

HCID 63642-Propanethiol

HCID 10584232Methyl 2-chloro-6-methoxynicotinate

Product 1

HCID 901182112-Isopropylsulfanyl-6-methoxy-nicotinic acid methyl esterYield 87%

Procedure

2-Chloro-6-methoxy-nicotinic acid methyl ester (52 mg, 0.26 mmol) obtained in Step B and isopropylthiol were reacted in the same manner as in Step B of Preparation Example 9 to obtain the title compound (54 mg, 87%).

Sources & evidence

ORD record: ord-047a99994fcd45d083d8029511e94176
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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