反应详情

Part C. A mixture of 4-(4-isopropyl-phenyl)-pyridine-N-oxide (126 mg, 0.59 mmol) and phosphorus oxychloride (5 mL) is heated to reflux for 12 h. The mixture is cooled and evaporated, and the residue is dissolved in water, neutralized with satd. aq. Na2CO3 and extracted with ethyl acetate. The extract is washed with brine, dried over magnesium sulfate, filtered and evaporated. The residue is separated by column chromatography to afford 2-chloro-4-(4-isopropyl-phenyl)-pyridine (110 mg, 81%).

1. temperatureis heated
2. temperatureto reflux for 12 h
3. temperatureThe mixture is cooled
4. customevaporated
5. dissolutionthe residue is dissolved in water
6. extractionaq. Na2CO3 and extracted with ethyl acetate
7. washThe extract is washed with brine
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customevaporated
11. customThe residue is separated by column chromatography