2-Propanethiol → 4-Isopropylsulfanyl-2-methyl-pyrimidine-5-carboxylic acid methyl ester

HRID 62886Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[C:6](Cl)=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[O:4].[CH3:13][CH:14]([SH:16])[CH3:15]>>[CH3:1][O:2][C:3]([C:5]1[C:6]([S:16][CH:14]([CH3:15])[CH3:13])=[N:7][C:8]([CH3:11])=[N:9][CH:10]=1)=[O:4]

Participants

Reactant 2

HCID 63642-Propanethiol

HCID 83697272Methyl 4-chloro-2-methylpyrimidine-5-carboxylate

Product 1

HCID 901181774-Isopropylsulfanyl-2-methyl-pyrimidine-5-carboxylic acid methyl esterYield 90%

Procedure

4-Chloro-2-methyl-pyrimidine-5-carboxylic acid methyl ester (0.105 g, 0.56 mmol) and 2-propanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.114 g, 90%).

Sources & evidence

ORD record: ord-754789530eb34c57855b6617a45abde8
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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