Sodium Carbonate → Methyl 4-(6-hydroxyquinolin-2-yl)benzoate

HRID 628882Notes

Reaction equation

HRID 628882 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](B(O)O)=[CH:7][CH:6]=1)=[O:4].Cl[C:15]1[CH:24]=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[C:20]([OH:25])[CH:21]=2)[N:16]=1.C([O-])([O-])=O.[Na+].[Na+]>>[OH:25][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][CH:19]=1)[N:16]=[C:15]([C:8]1[CH:9]=[CH:10][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=1)[CH:24]=[CH:23]2

Participants

4

Reactant 3

HCID 10340Sodium CarbonateHCID 27343694-Methoxycarbonylphenylboronic acidHCID 221325772-Chloroquinolin-6-ol

Product 1

HCID 66980069Methyl 4-(6-hydroxyquinolin-2-yl)benzoate

Procedure

Scheme 1, step 1, starting from 4-(methoxycarbonyl)phenylboronic acid and 2-chloroquinolin-6-ol, using Na2CO3 instead of TEA.

Sources & evidence

ORD record
ord-ea1125c044684100aca845f865cca8fa
Source dataset
uspto-grants-2016_04
Patent number
US09315462B2

Reaction notes

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