HRID628935

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)CP(=O)(OC)OC

HCID131735359

未命名化合物

结构：CCCC(CC(=O)/C=C/[C@@H]1[C@@H](CCCc2ccc(C(=O)OC)s2)[C@H](Cl)C[C@H]1OC1CCCCO1)O[Si](C)(C)C(C)(C)C

HCID131735361

未命名化合物

PRODUCTS

生成物

结构：CCCCC(O[Si](C)(C)C(C)(C)C)C(=O)/C=C/[C@@H]1[C@@H](CCCc2ccc(C(=O)OC)s2)[C@H](Cl)C[C@H]1OC1CCCCO1

HCID131735360

未命名化合物

收率 86%

PROCEDURE

实验过程

Compound 15 (1.32 g) was prepared in 86% yield by employing dimethyl (3-((tert-butyldimethylsilyl)oxy)-2-oxoheptyl)phosphonate 6 and aldehyde 10 according to the procedures described for compound 11 (see Schemes 1 and 2).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e3e8fb5732f74e46ace56968a7255bdd
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315486B2
来源说明: uspto-grants-2016_04

反应 SMILES

COP([CH2:7][C:8](=[O:22])[CH:9]([O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[CH2:10][CH2:11][CH2:12][CH3:13])(=O)OC.[Si](OC(CCC)CC(=O)/C=[CH:35]/[C@H:36]1[C@H:40]([O:41][CH:42]2[CH2:47][CH2:46][CH2:45][CH2:44][O:43]2)[CH2:39][C@@H:38]([Cl:48])[C@@H:37]1[CH2:49][CH2:50][CH2:51][C:52]1[S:56][C:55]([C:57]([O:59][CH3:60])=[O:58])=[CH:54][CH:53]=1)(C(C)(C)C)(C)C>>[Si:15]([O:14][CH:9]([CH2:10][CH2:11][CH2:12][CH3:13])[C:8](=[O:22])/[CH:7]=[CH:35]/[C@H:36]1[C@H:40]([O:41][CH:42]2[CH2:47][CH2:46][CH2:45][CH2:44][O:43]2)[CH2:39][C@@H:38]([Cl:48])[C@@H:37]1[CH2:49][CH2:50][CH2:51][C:52]1[S:56][C:55]([C:57]([O:59][CH3:60])=[O:58])=[CH:54][CH:53]=1)([C:18]([CH3:19])([CH3:20])[CH3:21])([CH3:16])[CH3:17]