HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl(3-((tert-butyldimethylsilyl)oxy)-2-oxoheptyl)phosphonate → Methyl 5-(3-((1R,2R,3R,5R)-2-((E)-4-((tert-butyldimethylsilyl)oxy)-3-oxooct-1-en-1-yl)-5-chloro-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)propyl)thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl(3-((tert-butyldimethylsilyl)oxy)-2-oxoheptyl)phosphonate | HCID 131735359 | — |
| Reactant | Methyl 5-(3-((1R,2R,3R,5R)-2-((E)-5-((tert-butyldimethylsilyl)oxy)-3-oxooct-1-en-1-yl)-5-chloro-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)propyl)thiophene-2-carboxylate | HCID 131735361 | — |
| Product | Methyl 5-(3-((1R,2R,3R,5R)-2-((E)-4-((tert-butyldimethylsilyl)oxy)-3-oxooct-1-en-1-yl)-5-chloro-3-((tetrahydro-2H-pyran-2-yl)oxy)cyclopentyl)propyl)thiophene-2-carboxylate | HCID 131735360 | 86% |
Reaction Steps
Compound 15 (1.32 g) was prepared in 86% yield by employing dimethyl (3-((tert-butyldimethylsilyl)oxy)-2-oxoheptyl)phosphonate 6 and aldehyde 10 according to the procedures described for compound 11 (see Schemes 1 and 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315486B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-e3e8fb5732f74e46ace56968a7255bdd |
| Source note | uspto-grants-2016_04 |