Sulfuric Acid → HCID 18757590, compound

HRID 62894Notes

Reaction equation

HRID 62894 reaction equation
S(=O)(=O)(O)O.[Cl:6][CH2:7][C:8](=O)[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].[F:16][C:17]1[C:23]([OH:24])=[C:22]([F:25])C=C[C:18]=1O>>[Cl:6][CH2:7][C:8]1[C:14]2[C:13](=[C:22]([F:25])[C:23]([OH:24])=[C:17]([F:16])[CH:18]=2)[O:12][C:10](=[O:11])[CH:9]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 69484Ethyl 4-chloroacetoacetateHCID 108445152,4-Difluororesorcinol

Product 1

HCID 18757590HCID 18757590, compoundYield 24%

Procedure

Sulfuric acid (2 mL) in a flask was cooled to 0° C. After ethyl 4-chloroacetoacetate (0.62 g, 3.8 mmol) was added thereto, 2,4-difluororesorcinol (0.5 g, 3.4 mmol) was added dropwise thereto. The mixture was stirred at room temperature for 2 hours, and the reactant was placed in ice water. The precipitate was filtered, washed with water, and dried by nitrogen gas to obtain the title compound (0.2 g, 24%).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried by nitrogen gas

Sources & evidence

ORD record
ord-a280cbbb94b44d6c87a7459224c1758d
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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