Hydrochloric Acid → HCID 178467331, compound

HRID 628974Notes

Reaction equation

HRID 628974 reaction equation
C(O[C:4](=[O:16])[C:5](=[C:9]1[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10]1)[O:6][CH2:7][CH3:8])C.[OH-:17].[K+].Cl>>[CH2:7]([O:6][C:5]1[C:9]([C:13]([OH:17])=[O:14])=[N:10][C:11]([OH:15])=[N:12][C:4]=1[OH:16])[CH3:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 67295487(2,5-Dioxo-imidazolidin-4-ylidene)-ethoxy-acetic acid ethyl ester

Product 1

HCID 178467331HCID 178467331, compound

Conditions

Temperature
0 °C

Procedure

(2,5-dioxo-imidazolidin-4-ylidene)-ethoxy-acetic acid ethyl ester (16.02 g, 1 eq.) was dissolved in aq. 1 N KOH (281 ml, 4 eq.) and refluxed for 3.5 hrs. The mixture was cooled to 0° C. and carefully acidified with conc. HCl. After overnight cooling (4° C.), it led to the formation of white precipitate. The mixture was filtered and the precipitate was dried in vacuo. The product obtained was a white solid (7.76 g, 55%).

Workup

  1. temperaturerefluxed for 3.5 hrs
  2. temperatureAfter overnight cooling (4° C.), it
  3. filtrationThe mixture was filtered
  4. customthe precipitate was dried in vacuo
  5. customThe product obtained

Sources & evidence

ORD record
ord-cfbb445fc17b4100b664f334c145addd
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

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