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温度

0 °C

(2,5-dioxo-imidazolidin-4-ylidene)-ethoxy-acetic acid ethyl ester (16.02 g, 1 eq.) was dissolved in aq. 1 N KOH (281 ml, 4 eq.) and refluxed for 3.5 hrs. The mixture was cooled to 0° C. and carefully acidified with conc. HCl. After overnight cooling (4° C.), it led to the formation of white precipitate. The mixture was filtered and the precipitate was dried in vacuo. The product obtained was a white solid (7.76 g, 55%).

1. temperaturerefluxed for 3.5 hrs
2. temperatureAfter overnight cooling (4° C.), it
3. filtrationThe mixture was filtered
4. customthe precipitate was dried in vacuo
5. customThe product obtained