Dicyclohexylcarbodiimide → HCID 70975381, compound

HRID 629002Notes

Reaction equation

HRID 629002 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:21]([O:30][CH3:31])=[CH:20][N:19]=2)=[CH:14][CH:13]=1)=S.C1CCC(N=C=NC2CCCCC2)CC1>C1COCC1>[NH:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[N:1]=[C:9]1[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[N:23]=[C:22]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)[C:21]([O:30][CH3:31])=[CH:20][N:19]=2)=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 10868DicyclohexylcarbodiimideHCID 86673491HCID 86673491, compound

Product 1

HCID 70975381HCID 70975381, compoundYield 68.36%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-(2-Amino-phenyl)-3-[4-(5-methoxy-4-morpholin-4-yl-pyrimidin-2-yl)-phenyl]-thiourea (0.3 g, 1.0 eq.) and DCC (0.18 g, 1.3 eq.) in THF (10 ml) for 9 hrs at 80-90° C. The mixture was dried in vacuo, crystallized in a EA solution, and then filtered to give a white solid (0.18 g, 68.36%), which was then dried in vacuo to give of a product.

Workup

  1. customThe mixture was dried in vacuo
  2. customcrystallized in a EA solution
  3. filtrationfiltered

Sources & evidence

ORD record
ord-da8e69bf8da34457ab333ecfc4b546e1
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

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