反应详情

温度

100 °C

The NaOCH3 (8.5 g, 157 mmole), was added to a stirred solution of dimethyl 2-methoxymalonate (10.2 g, 62.91 mmole), urea (2.5 g, 41.7 mmole), and EtOH (80 ml). The reaction mixture was heated to 100° C. for 4 hrs, then the reaction was evaporated to remove the solvent. Water was added to the mixture and then concentrated HCl was added. The pH of the mixture was adjusted to ca. 3˜4. The mixture was filtered and wash water and acetone. After drying in vacuo, it gave a product (99%).

1. customthe reaction was evaporated
2. customto remove the solvent
3. additionWater was added to the mixture
4. additionconcentrated HCl was added
5. filtrationThe mixture was filtered
6. washwash water and acetone
7. customAfter drying in vacuo, it