Morpholine → HCID 86673511, compound

HRID 629032Notes

Reaction equation

HRID 629032 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:13]([O:14][CH3:15])=[C:12](Cl)[N:11]=[C:10]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)[N:9]=1>C1COCC1>[Cl:7][C:8]1[N:9]=[C:10]([C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)[N:11]=[C:12]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[C:13]=1[O:14][CH3:15]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 86673512HCID 86673512, compound

Product 1

HCID 86673511HCID 86673511, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Morpholine (0.6 ml, 2.2 eq) was added to a stirred solution of 4,6-dichloro-5-methoxy-2-(4-nitrophenyl)pyrimidine (0.87 g, 1 eq) in THF, the mixture was stirred at r.t for 4 hrs, the solvent was evaporated, water was added to the solution and the solution was extracted with EA. The combined organic layers were washed with brine, dried and evaporated in vacuo, the product was obtained as a yellow solid (56%).

Workup

  1. customthe solvent was evaporated
  2. additionwater was added to the solution
  3. extractionthe solution was extracted with EA
  4. washThe combined organic layers were washed with brine
  5. customdried
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-719061368f2b4f23b5619faea3a48042
Source dataset
uspto-grants-2016_04
Patent number
US09315491B2

Reaction notes

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