5-Bromonicotinic acid → 5-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamide

HRID 629103Notes

Reaction equation

HRID 629103 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:11][C:12]([F:22])([F:21])[O:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:18][C:17]1[CH:19]=[CH:20][C:14]([O:13][C:12]([F:11])([F:21])[F:22])=[CH:15][CH:16]=1)=[O:9]

Participants

3

Reactant 2

HCID 887075-Bromonicotinic acidHCID 6008484-(Trifluoromethoxy)aniline

Product 1

HCID 46840185-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamide

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 59.1 using 5-bromonicotinic acid and 4-(trifluoromethoxy)aniline to afford white crystals. UPLC-MS (Condition 2) tR=1.11 min, 361.1/363 [M+H]+.

Workup

  1. customto afford white crystals

Sources & evidence

ORD record
ord-4c8a40d1e07647159115a23c238937e7
Source dataset
uspto-grants-2016_04
Patent number
US09315489B2

Reaction notes

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