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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 629103Generated: October 30, 2026

5-Bromonicotinic acid → 5-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamide

https://huagongshe.com/reaction/629103

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Bromonicotinic acidHCID 88707—
Reactant4-(Trifluoromethoxy)anilineHCID 600848—
Product5-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamideHCID 4684018—

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Stage 59.1 using 5-bromonicotinic acid and 4-(trifluoromethoxy)aniline to afford white crystals. UPLC-MS (Condition 2) tR=1.11 min, 361.1/363 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315489B2
Source datasetuspto-grants-2016_04
ORD IDord-4c8a40d1e07647159115a23c238937e7
Source noteuspto-grants-2016_04