反应详情

温度

100 °C

A mixture of 5-bromo-N-(4-(trifluoromethoxy)phenyl)nicotinamide (Stage 42.1, 5 g, 13.85 mmol), 3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (3.5 g, 15.23 mmol), PdCl2(dppf) (0.507 g, 0.692 mmol), K3PO4 (8.82 g, 41.5 mmol), EtOH (9.33 mL), water (14 mL) and toluene (70 mL) was stirred at 100° C. for 1 h. The solvent was evaporated off under reduced pressure and the residue was treated with water and extracted with EtOAc. The combined extracts were washed with water and brine, dried over Na2SO4 and the solvent was evaporated off under reduced pressure. The residue was purified by flash chromatography (Silica gel column, 500 g, EtOAc/MeOH from 0 to 2% MeOH). Fractions containing the pure product were combined and the solvent was evaporated off under reduced pressure to give a residue which was dissolved in THF, stirred overnight with Si-Thiol (1 g), filtered and the filtrate was evaporated off under reduced pressure to give the title compound as a white solid. UPLC-MS (Condition 7) tR=1.03 min, m/z=376 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm 7.43 (d, J=8.93 Hz, 2H) 7.91 (d, J=9.0 Hz, 2H) 8.32 (dd, J=2.20 Hz, 1H) 8.71 (d, J=2.32 Hz, 1H) 9.0 (d, J=5.1 Hz, 1H) 9.15 (s, 1H) 9.22 (s, 1H) 10.69 (s, 1H).

1. customThe solvent was evaporated off under reduced pressure
2. additionthe residue was treated with water
3. extractionextracted with EtOAc
4. washThe combined extracts were washed with water and brine
5. dry with materialdried over Na2SO4
6. customthe solvent was evaporated off under reduced pressure
7. customThe residue was purified by flash chromatography (Silica gel column, 500 g, EtOAc/MeOH from 0 to 2% MeOH)
8. additionFractions containing the pure product
9. customthe solvent was evaporated off under reduced pressure
10. customto give a residue which
11. filtrationfiltered
12. customthe filtrate was evaporated off under reduced pressure