4-(Chlorodifluoromethoxy)aniline → 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide

HRID 629121Notes

Reaction equation

HRID 629121 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][C:3]=1[I:11].[Cl:12][C:13]([F:23])([F:22])[O:14][C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1>>[Cl:1][C:2]1[C:3]([I:11])=[CH:4][C:5]([C:8]([NH:19][C:18]2[CH:20]=[CH:21][C:15]([O:14][C:13]([Cl:12])([F:22])[F:23])=[CH:16][CH:17]=2)=[O:10])=[CH:6][N:7]=1

Participants

3

Reactant 2

HCID 5727934-(Chlorodifluoromethoxy)anilineHCID 222714776-Chloro-5-iodonicotinic acid

Product 1

HCID 867026266-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 65.1 using 6-Chloro-5-iodo-3-pyridinecarboxylic acid and 4-(chlorodifluoromethoxy)aniline to afford a beige solid. UPLC-MS (Condition 2) tR=1.25 min, m/z=459.0/460.7/462.1 [M+H]+.

Workup

  1. customto afford a beige solid

Sources & evidence

ORD record
ord-0b2b9f36109246c198275f7d2ba95f36
Source dataset
uspto-grants-2016_04
Patent number
US09315489B2

Reaction notes

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