5-Bromothiophene-2-carbaldehyde → HCID 118228960, compound

HRID 629130Notes

Reaction equation

HRID 629130 reaction equation
Br[C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1.[CH2:9](B(O)O)[CH2:10][CH:11]=[CH2:12]>>[CH2:12]([C:2]1[S:6][C:5]([CH:7]=[O:8])=[CH:4][CH:3]=1)[CH2:11][CH:10]=[CH2:9]

Participants

3

Reactant 2

HCID 784285-Bromothiophene-2-carbaldehydeHCID 20827003But-3-en-1-ylboronic acid

Product 1

HCID 118228960HCID 118228960, compoundYield 55%

Procedure

The compound was synthesized as in Example 3.1 using 5-bromo-2-formylthiophene (191 mg, 1.0 mmol) in place of 5-bromo-2-formylfuran and 3-butenylboronic acid (150 mg, 1.5 mmol) in place of hexylboronic acid to give 5-(3-butenyl)-2-formylthiophene (91 mg, 55%). Used without further characterization.

Sources & evidence

ORD record
ord-ed5a3e92483f4f2ea60c3a8f53eed495
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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