4-Bromobenzaldehyde → HCID 118230497, compound

HRID 629148Notes

Reaction equation

HRID 629148 reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[F:10][C:11]([F:19])([F:18])[CH2:12][CH2:13][B-](F)(F)F>>[F:10][C:11]([F:19])([F:18])[CH2:12][CH2:13][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 707414-BromobenzaldehydeHCID 56972907HCID 56972907, compound

Product 1

HCID 118230497HCID 118230497, compoundYield 89.4%

Procedure

The compound was synthesized as in Example 3.1 using 4-bromobenzaldehyde (250 mg, 1.35 mmol) in place of 5-bromo-2-formylfuran and 3,3,3-trifluoropropyltrifluoroborate (455 mg, 2.23 mmol) in place of hexylboronic acid to give 4-(3,3,3-trifluoropropyl)benzaldehyde (244 mg, 89%). Used without further characterization.

Sources & evidence

ORD record
ord-cac53f6e0eb24bc586e249c2a7381876
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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