Isopropyl iodide → 2-Methyl-4-[(propan-2-yl)oxy]benzaldehyde

HRID 629182Notes

Reaction equation

HRID 629182 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[CH:3]=1.I[CH:12]([CH3:14])[CH3:13]>>[CH3:10][C:4]1[CH:3]=[C:2]([O:1][CH:12]([CH3:14])[CH3:13])[CH:9]=[CH:8][C:5]=1[CH:6]=[O:7]

Participants

3

Reactant 2

HCID 6362Isopropyl iodideHCID 4581854-Hydroxy-2-methylbenzaldehyde

Product 1

HCID 130879782-Methyl-4-[(propan-2-yl)oxy]benzaldehydeYield 76%

Procedure

The compound was synthesized as in Example 87.1, using 4-hydroxy-2-methylbenzaldehyde (54.4 mg, 0.40 mmol) in place of 4-hydroxybenzaldehyde and 2-iodopropane (100 μL, 0.80 mmol) in place of 1-iodo-(3,3,3-trifluoro)propane to give 2-methyl-4-isopropoxybenzaldehyde (54 mg, 76%). Used without further characterization.

Workup

  1. customThe compound was synthesized as in Example 87.1

Sources & evidence

ORD record
ord-a5a6120f75b04621a2d6eaa3f1d42723
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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