4-Hydroxy-2-methylbenzaldehyde → HCID 82005921, compound

HRID 629183Notes

Reaction equation

HRID 629183 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[CH:3]=1.[F:11][CH:12]([F:15])[CH2:13]I>>[F:11][CH:12]([F:15])[CH2:13][O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[CH:3]=1

Participants

3

Reactant 2

HCID 4581854-Hydroxy-2-methylbenzaldehydeHCID 38335651,1-Difluoro-2-iodoethane

Product 1

HCID 82005921HCID 82005921, compoundYield 68%

Procedure

The compound was synthesized as in Example 87.1, using 4-hydroxy-2-methylbenzaldehyde (54.4 mg, 0.40 mmol) in place of 4-hydroxybenzaldehyde and 2,2-difluoro-1-iodoethane (153 mg, 0.80 mmol) in place of 1-iodo-(3,3,3-trifluoro)propane to give 4-(2,2-difluoroethoxy)-2-methylbenzaldehyde (54 mg, 68%). Used without further characterization.

Workup

  1. customThe compound was synthesized as in Example 87.1

Sources & evidence

ORD record
ord-bfe1137986d6430ab6b9f7081bb9d923
Source dataset
uspto-grants-2016_04
Patent number
US09315495B2

Reaction notes

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