反应详情

温度

140 °C

To 5,7-dichloro-3H-pyrido[3,4-d]pyridazin-4-one (180 mg, 0.833 mmol) in DMSO (1 ml) in a sealable vial, was added DIPEA (0.189 ml, 1.083 mmol) and 3-methyl-1H-indol-7-amine (158 mg, 1.083 mmol). The vial was capped to close and the mixture heated on a sandbath at 140° C. for 1 h. The resultant mixture was poured into water (20 ml), and extracted with EtOAc (20 ml). Organic phase was washed with water then brine, dried over Na2SO4, then concentrated under vacuum. The residue was triterated with DCM, then collected by filtration and dried to give title compound as a yellow-mustard coloured solid.

1. customThe vial was capped
2. customto close
3. extractionextracted with EtOAc (20 ml)
4. washOrganic phase was washed with water
5. dry with materialbrine, dried over Na2SO4
6. concentrationconcentrated under vacuum
7. filtrationcollected by filtration
8. customdried