2,4-Difluorophenylboronic acid → 6-Bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine

HRID 629267Notes

Reaction equation

HRID 629267 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8](I)=[CH:9][N:10]=2)[CH:7]=1.[F:12][C:13]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:14]=1B(O)O>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:16]3[CH:15]=[CH:14][C:13]([F:12])=[CH:18][C:17]=3[F:19])=[CH:9][N:10]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 220316326-Bromo-3-iodoimidazo(1,2-a)pyridine

Product 1

HCID 901893056-Bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine

Procedure

The title compound, off-white solid (0.33 g, 49%), MS (ISP) m/z=309.4 [(M+H)+], mp 137.5° C., was prepared in accordance with the general method of intermediate E from commercially available 6-bromo-3-iodoimidazo[1,2-a]pyridine (0.7 g, 2.17 mmol) and commercially available 2,4-difluoro-phenylboronic acid (0.38 g, 2.38 mmol).

Sources & evidence

ORD record
ord-cf6fe744201e4874b815198a58e4607d
Source dataset
uspto-grants-2016_04
Patent number
US09315502B2

Reaction notes

Loading…