反应详情

温度

120 °C

To a solution of 3-bromo-2-methylphenol (20.0 g) in DMF (250 mL) were added copper(I) cyanide (19.0 g) and tetrakis(triphenylphosphine)palladium(0) (3.70 g), and the mixture was heated with stirring at 120° C. for 16 hr under nitrogen atmosphere. The reaction mixture was poured into water, and the mixture was filtered. The filtrate was extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was washed with tert-butyl methyl ether to give the title compound (7.00 g).

1. temperaturethe mixture was heated
2. filtrationthe mixture was filtered
3. extractionThe filtrate was extracted with ethyl acetate
4. dry with materialthe organic layer was dried over anhydrous sodium sulfate
5. customThe solvent was evaporated under reduced pressure
6. washthe residue was washed with tert-butyl methyl ether