Hydrogen Bromide → HCID 89201239, compound

HRID 629391Notes

Reaction equation

HRID 629391 reaction equation
[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[BrH:13].O>CS(C)=O>[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([CH3:12])[C:8]([Br:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 962WaterHCID 2824502-Amino-3,4-dimethylbenzoic acid

Product 1

HCID 89201239HCID 89201239, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 2-amino-3,4-dimethylbenzoic acid (50.0 g) in DMSO (500 mL) was added hydrobromic acid (174 mL) while keeping the internal temperature at 25 to 30° C., and the mixture was stirred overnight at room temperature. To the reaction mixture was added water (500 mL), and the mixture was stirred for 30 min. The precipitate was collected by filtration, and washed with water to give the title compound (102 g: containing DMSO).

Workup

  1. customat 25 to 30° C.
  2. stirringthe mixture was stirred for 30 min
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-b1618edb95fb424cab59b35fc1ade5a6
Source dataset
uspto-grants-2016_04
Patent number
US09315458B2

Reaction notes

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