HCID 59419852, compound → 3-[4-(6-Sec-butylsulfanyl-pyridin-2-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acid ethyl ester

HRID 62941Notes

Reaction equation

HRID 62941 reaction equation
[CH:1]([S:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12]Cl)[N:7]=1)([CH2:3][CH3:4])[CH3:2].[CH2:14]([O:16][C:17](=[O:30])[CH:18]([CH3:29])[CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([OH:27])=[C:22]([F:28])[CH:21]=1)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:30])[CH:18]([CH3:29])[CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([O:27][CH2:12][C:8]2[CH:9]=[CH:10][CH:11]=[C:6]([S:5][CH:1]([CH2:3][CH3:4])[CH3:2])[N:7]=2)=[C:22]([F:28])[CH:21]=1)[CH3:15]

Participants

3

Reactant 2

HCID 59419852HCID 59419852, compoundHCID 90117937HCID 90117937, compound

Product 1

HCID 901180443-[4-(6-Sec-butylsulfanyl-pyridin-2-ylmethoxy)-3,5-difluoro-phenyl]-2-methyl-propionic acid ethyl esterYield 96%

Procedure

2-sec-Butylsulfanyl-6-chloromethyl-pyridine (28 mg, 0.13 mmol) in Step C of Preparation Example 5 and 3-(3,5-difluoro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (30 mg, 0.13 mmol) in Step B of Preparation Example 34 were used to react in the same manner as in Step A of Example 1 to obtain the title compound (50 mg, 96%).

Workup

  1. customin Step B of Preparation Example 34
  2. customto react in the same manner as in Step A of Example 1

Sources & evidence

ORD record
ord-6541f957eb964f589f0a641155eedddf
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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