N,N-Dimethylethylenediamine → HCID 71542195, compound

HRID 629528Notes

Reaction equation

HRID 629528 reaction equation
[C:1]12([C:11]3[CH:22]=[CH:21][C:14]([O:15][CH2:16][CH2:17][C:18](O)=[O:19])=[C:13]([CH3:23])[CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:24][N:25]([CH3:29])[CH2:26][CH2:27][NH2:28]>>[C:1]12([C:11]3[CH:22]=[CH:21][C:14]([O:15][CH2:16][CH2:17][C:18]([NH:28][CH2:27][CH2:26][N:25]([CH3:29])[CH3:24])=[O:19])=[C:13]([CH3:23])[CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 86729432HCID 86729432, compound

Product 1

HCID 71542195HCID 71542195, compoundYield 94.1%

Procedure

The title compound was prepared from 3-(4-(adamantan-1-yl)-2-methylphenoxy)propanoic acid (0.2 g, 0.63 mmol) and N,N-dimethylethane-1,2-diamine (0.056 g, 0.63 mmol) according to the example 1, which was given 3-(4-(adamantan-1-yl)-2-methylphenoxy)-N-(2-(dimethylamino)ethyl)propanamide as a white solid (0.228 g, 93.4% yield).

Sources & evidence

ORD record
ord-545625f1aa0847b4b39970f744d4a715
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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