N,N-Dimethylethylenediamine → HCID 71542198, compound

HRID 629534Notes

Reaction equation

HRID 629534 reaction equation
[C:1]12([C:11]3[CH:23]=[CH:22][C:14]([O:15][C:16]([CH3:21])([CH3:20])[C:17](O)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:24][N:25]([CH3:29])[CH2:26][CH2:27][NH2:28]>>[C:1]12([C:11]3[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:20])([CH3:21])[C:17]([NH:28][CH2:27][CH2:26][N:25]([CH3:29])[CH3:24])=[O:18])=[CH:22][CH:23]=3)[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 86729434HCID 86729434, compound

Product 1

HCID 71542198HCID 71542198, compoundYield 94.1%

Procedure

The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)-2-methylpropanoic acid (0.2 g, 0.63 mmol), prepared from the step 2 of example 23, and N,N-dimethylethane-1,2-diamine (0.056 g, 0.63 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-N-(2-(dimethylamino)ethyl)-2-methylpropanamide as a white solid (0.228 g, 93.4% yield).

Sources & evidence

ORD record
ord-f7bbb2a0dbf84835874e7068404cd3f5
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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