PMID26882240-Compound-8 → 2-(4-(Adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanone

HRID 629538Notes

Reaction equation

HRID 629538 reaction equation
[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17]([OH:19])=O)=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[F:22][C:23]([F:38])([F:37])[C:24]1[CH:36]=[CH:35][C:27]([CH2:28][N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)=[CH:26][CH:25]=1>>[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17]([N:32]4[CH2:31][CH2:30][N:29]([CH2:28][C:27]5[CH:26]=[CH:25][C:24]([C:23]([F:37])([F:38])[F:22])=[CH:36][CH:35]=5)[CH2:34][CH2:33]4)=[O:19])=[CH:13][CH:12]=3)[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

3

Reactant 2

HCID 625381PMID26882240-Compound-8HCID 27828031-[4-(Trifluoromethyl)benzyl]piperazine

Product 1

HCID 715422892-(4-(Adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanoneYield 94%

Procedure

The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)acetic acid (0.3 g, 1.04 mmol) and 1-(4-(trifluoromethyl)benzyl)piperazine (0.255 g, 1.04 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanone as a white solid (0.501 g, 93.3% yield).

Sources & evidence

ORD record
ord-a7769d8da52e44b7926fd8841f1a944a
Source dataset
uspto-grants-2016_04
Patent number
US09315507B2

Reaction notes

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