HuagongsheHuagongshe Chemistry Print Report · For research reference only
PMID26882240-Compound-8 → 2-(4-(Adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | PMID26882240-Compound-8 | HCID 625381 | — |
| Reactant | 1-[4-(Trifluoromethyl)benzyl]piperazine | HCID 2782803 | — |
| Product | 2-(4-(Adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanone | HCID 71542289 | 94% |
Reaction Steps
The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)acetic acid (0.3 g, 1.04 mmol) and 1-(4-(trifluoromethyl)benzyl)piperazine (0.255 g, 1.04 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-1-(4-(4-(trifluoromethyl)benzyl)piperazin-1-yl) ethanone as a white solid (0.501 g, 93.3% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315507B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a7769d8da52e44b7926fd8841f1a944a |
| Source note | uspto-grants-2016_04 |