2-Chloroanisole → HCID 86729438, compound

HRID 629551Notes

Reaction equation

Br[C:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19][CH3:20]>>[Cl:12][C:13]1[CH:18]=[C:17]([C:2]23[CH2:11][CH:6]4[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]4)[CH2:3]2)[CH2:9]3)[CH:16]=[CH:15][C:14]=1[O:19][CH3:20]

Participants

Reactant 2

HCID 130112-Chloroanisole

HCID 791061-Bromoadamantane

Product 1

HCID 86729438HCID 86729438, compoundYield 84.4%

Procedure

The title compound was prepared from 1-chloro-2-methoxybenzene (10 mL) and 1-bromoadamantane (3.25 g, 15.25 mmol) according to the step 1 of the example 5, which was given 1-(3-chloro-4-methoxyphenyl)adamantane (3.52 g, 84.4% yield).

Sources & evidence

ORD record: ord-5e6b127508bf4d649ba0a37093b3eea4
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315507B2

Reaction notes

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