Hydrochloric Acid → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

HRID 629593Notes

Reaction equation

HRID 629593 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.Cl>ClCCl>[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

Product 1

HCID 225621451-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 173A (52.57 g) in dichloromethane (900 mL) was treated with 4M HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

Workup

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b201bed9c4a047e2bd629fdd0012290f
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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