4-Chloro-3-nitrobenzenesulfonamide → HCID 67126605, compound

HRID 629597Notes

Reaction equation

HRID 629597 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].Cl.Cl.[NH2:17][CH2:18][C:19]1([NH2:25])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.C(N(CC)CC)C>O1CCOCC1.O>[NH2:25][C:19]1([CH2:18][NH:17][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

6

Reactant 3

HCID 73244-Chloro-3-nitrobenzenesulfonamideHCID 8471TriethylamineHCID 67227314HCID 67227314, compound

Product 1

HCID 67126605HCID 67126605, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-chloro-3-nitrobenzenesulfonamide, 4-(aminomethyl)tetrahydro-2H-pyran-4-amine bis-hydrochloric acid salt and triethylamine in dioxane (10 mL) was heated at 110° C. overnight. After cooling, the reaction mixture was diluted with water (10 mL), and the solid was filtered to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered

Sources & evidence

ORD record
ord-c971370e1e9d4650b2dfc40f789a3d1b
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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