Trifluoroacetic acid → Trifluoroacetic acid

HRID 629603Notes

Reaction equation

HRID 629603 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[C:9]=2[CH2:20][N:21]2[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]2)=[CH:4][CH:3]=1.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[C:9]=2[CH2:20][N:21]2[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]2)=[CH:4][CH:3]=1.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67144758HCID 67144758, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67145281HCID 67145281, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a mixture of EXAMPLE 199B (2 g) in dichloromethane (10 ml) was added trifluroacetic acid (10 ml) at 0° C. The reaction mixture was stirred at room temperature for 30 minutes and concentrated. The residue was loaded onto a C18 column, and eluted with 0-50% 0.1% trifluroacetic acid/water in acetonitrile. The title compound was obtained as a trifluroacetic acid salt.

Workup

  1. concentrationconcentrated
  2. washeluted with 0-50% 0.1% trifluroacetic acid/water in acetonitrile

Sources & evidence

ORD record
ord-ef7c3c848832455e93e354df5a5cf24d
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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