Diisopropylethylamine → HCID 67169233, compound

HRID 629660Notes

Reaction equation

HRID 629660 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1[NH:22][CH:19]1[CH2:20][CH2:21][N:16]([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 47309215,6-Dichloropyridine-3-sulfonamideHCID 162276441-Cyclopropylpiperidin-4-amine

Product 1

HCID 67169233HCID 67169233, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of EXAMPLE 387A (0.4 g), 1-cyclopropylpiperidin-4-amine (0.3 g) and N,N-diisopropylethylamine (0.37 mL) in dioxane (3 mL) was heated at 100° C. for 18 hours. The crude product was isolated by concentration and was purified on silica gel, which was eluted with ethyl acetate to give the title compound.

Workup

  1. customThe crude product was isolated by concentration
  2. customwas purified on silica gel, which
  3. washwas eluted with ethyl acetate

Sources & evidence

ORD record
ord-ed253b65f4a442e0bacf70ddbd192e70
Source dataset
uspto-grants-2016_04
Patent number
US09315488B2

Reaction notes

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