Trifluoroacetic acid → HCID 68697241, compound

HRID 629669Notes

Reaction equation

HRID 629669 reaction equation
C([O:5][C:6](=[O:38])[C@H:7]([CH2:29][CH2:30][C:31]([O:33]C(C)(C)C)=[O:32])[NH:8][NH:9][C:10](=[O:28])[C:11]1[CH:16]=[CH:15][C:14]([NH:17]C(OC(C)(C)C)=O)=[CH:13][C:12]=1[N+:25]([O-:27])=[O:26])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([C:10]([NH:9][NH:8][C@H:7]([C:6]([OH:38])=[O:5])[CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[O:28])=[C:12]([N+:25]([O-:27])=[O:26])[CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68695638di-tert-butyl N-(4-(tert-butoxycarbonylamino)-2-nitrobenzamido)-L-glutamate

Product 1

HCID 68697241HCID 68697241, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of di-tert.-butyl-N-(4-(tert-butoxycarbonylamino)-2-nitrobenzamido)-L-glutamate in 53 ml dichloromethane were added 53 ml of trifluoroacetic acid at 0° C. under argon. After 1 hour at room temperature the mixture was concentrated to dryness to give 3.54 g of N-(4-amino-2-nitrobenzamido)-L-glutamic acid as a yellow foam.

Workup

  1. concentrationAfter 1 hour at room temperature the mixture was concentrated to dryness

Sources & evidence

ORD record
ord-c05194bb634b489fa3f67b5ff33364c3
Source dataset
uspto-grants-2016_04
Patent number
US09315506B2

Reaction notes

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