HCID 58566718, compound → 3-[3-Chloro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acid

HRID 62967Notes

Reaction equation

HRID 62967 reaction equation
Cl[CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1.C([O:15][C:16](=[O:28])[CH:17]([CH3:27])[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[C:21]([Cl:26])[CH:20]=1)C>>[Cl:26][C:21]1[CH:20]=[C:19]([CH2:18][CH:17]([CH3:27])[C:16]([OH:28])=[O:15])[CH:24]=[CH:23][C:22]=1[O:25][CH2:2][C:3]1[C:4]([S:9][CH2:10][CH2:11][CH3:12])=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 58566718HCID 58566718, compoundHCID 901182823-Chloromethyl-2-propylsulfanyl-pyridine

Product 1

HCID 742228883-[3-Chloro-4-(2-propylsulfanyl-pyridin-3-ylmethoxy)-phenyl]-2-methyl-propionic acidYield 75%

Procedure

3-Chloromethyl-2-propylsulfanyl-pyridine (32 mg, 0.15 mmol) obtained in Step C of Preparation Example 14 and 3-(3-chloro-4-hydroxy-phenyl)-2-methyl-propionic acid ethyl ester (42 mg, 0.17 mmol) obtained in Step B of Preparation Example 46 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (40 mg, 75%).

Workup

  1. customto react sequentially in the same manner as in Steps A and B of Example 1

Sources & evidence

ORD record
ord-8091803f94b64cb284f242bda7d2f21a
Source dataset
uspto-grants-2016_09
Patent number
US09447044B2

Reaction notes

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