HRID629701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN(C(=O)OC(C)(C)C)[C@H](C(=O)O)CO1)C(c1ccccc1)c1ccccc1

HCID86726308

未命名化合物

PRODUCTS

生成物

结构：COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H]1CN[C@H](C(=O)O)CO1)C(c1ccccc1)c1ccccc1

HCID86578073

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

4M HCl in dioxane was added to a solution of (3S,6R)-4-(tert-butoxycarbonyl)-6-[2-(2-{[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]amino}phenyl)ethyl]morpholine-3-carboxylic acid in Dioxane at room temperature and the reaction stirred until complete by LC/MS (8 hrs). The solvent was removed in vacuo to afford the title compound, LC/MS.M+1, +ESI=532.3

WORKUP

后处理

customThe solvent was removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6e3842a570204a7eb4f0b4948bf2c145
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09315475B2
来源说明: uspto-grants-2016_04

反应 SMILES

Cl.C(OC([N:9]1[CH2:14][C@@H:13]([CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[NH:23][C:24](=[O:44])[C@H:25]([CH:31]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[NH:26][C:27]([O:29][CH3:30])=[O:28])[O:12][CH2:11][C@H:10]1[C:45]([OH:47])=[O:46])=O)(C)(C)C>O1CCOCC1>[CH3:30][O:29][C:27]([NH:26][C@H:25]([C:24]([NH:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][CH2:15][C@@H:13]1[CH2:14][NH:9][C@H:10]([C:45]([OH:47])=[O:46])[CH2:11][O:12]1)=[O:44])[CH:31]([C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)=[O:28]