反应详情

N-(5-Fluoro-4-iodopyridin-3-yl)-2,2-dimethylpropanamide (8.46 g, 26.3 mmol) was heated at reflux in aqueous 3M HCl for 2 hours. The reaction was carefully quenched with aqueous sodium hydroxide (3M) until basic and the mixture was extracted with dichloromethane (×3). The combined organic fractions were dried (MgSO4), filtered and the solvent was evaporated under reduced pressure to afford the title compound (5.16 g, 21.7 mmol, 83% yield) as an off white solid, MS (ESI): m/z=239.18 (MH+), 90% pure by LCMS.

1. customThe reaction was carefully quenched with aqueous sodium hydroxide (3M) until basic and the mixture
2. extractionwas extracted with dichloromethane (×3)
3. dry with materialThe combined organic fractions were dried (MgSO4)
4. filtrationfiltered
5. customthe solvent was evaporated under reduced pressure