反应详情

Triphenylphosphine (31.2 g, 119 mmol) was added to a solution of 2-(bromomethyl)-1-fluoro-3-nitrobenzene (27.9 g, 119 mmol) in Acetonitrile (445 mL) (degassed with nitrogen) and the reaction stirred at ambient temperature for 10 min then heated to 85° C. for 2 hrs. The solvent was evaporated under reduced pressure to afford the title compound (59.1 g, 119 mmol, 100% yield) as a yellow powder, MS (ESI): m/z=416.2 (MH+); 100% pure by LCMS.

1. temperaturethen heated to 85° C. for 2 hrs
2. customThe solvent was evaporated under reduced pressure