Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 629835Generated: November 1, 2026

Buprenorphine component OF alks-5461 → 17-allyl-7alpha-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5alpha-epoxy-3,6-dihydroxy-6alpha,14alpha-ethanomorphinan

https://huagongshe.com/reaction/629835

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBuprenorphine component OF alks-5461HCID 9848990—
Reactant17-cyclopropylmethyl-7alpha-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5alpha-epoxy-3,6-dihydroxy-6alpha,14alpha-ethanomorphinanHCID 86711659—
Reactant17-allyl-7alpha-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5alpha-epoxy-3-hydroxy-6-methoxy-6alpha,14alpha-ethanomorphinanHCID 86711662—
Product17-allyl-7alpha-[(2S)-3,3-dimethyl-2-hydroxybutan-2-yl]-4,5alpha-epoxy-3,6-dihydroxy-6alpha,14alpha-ethanomorphinanHCID 8671166375.8%

Reaction Steps

Compound 16 was synthesized similar to the procedure described in Example 1 for the preparation of compound 2 using compound 15 rather than compound 1. After column chromatography, 4.0 g of compound 16 (75.8%) was obtained with a purity of 98.5%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09315514B2
Source datasetuspto-grants-2016_04
ORD IDord-fde15df01f84463c9c11d56a4c5b73fe
Source noteuspto-grants-2016_04