HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (4bS,8R,8aR,9aR,10S,13aR,13bR)-10-tert-butyl-5,6,7,8,9,9a,10,13b-octahydro-1-methoxy-7,10-dimethyl-8a,13a-ethano-4,8-methanobenzofuro[3,2-e][1,3]dioxino[4,5-g]isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | (4bS,8R,8aS,9aR,10S,13aR,13bR)-10-tert-butyl-7-cyclopropylmethyl-5,6,7,8,9,9a,10,13b-octahydro-10-methyl-8a,13a-ethano-4,8-methanobenzofuro[3,2-e][1,3]dioxino[4,5-g]isoquinolin-1-ol | HCID 73211769 | — |
| Reactant | (4bS,8R,8aS,9aR,10S,13aR,13bR)-1-benzyloxy-10-tert-butyl-7-cyclopropylmethyl-5,6,7,8,9,9a,10,13b-octahydro-10-methyl-8a,13a-ethano-4,8-methanobenzofuro[3,2-e][1,3]dioxino[4,5-g]isoquinoline | HCID 121278739 | — |
| Product | (4bS,8R,8aR,9aR,10S,13aR,13bR)-10-tert-butyl-5,6,7,8,9,9a,10,13b-octahydro-1-methoxy-7,10-dimethyl-8a,13a-ethano-4,8-methanobenzofuro[3,2-e][1,3]dioxino[4,5-g]isoquinoline | HCID 86711667 | 81.3% |
Reaction Steps
The title compound 23 was synthesized similar to the procedure described in Example 5 for preparing compound 7 using methyl iodide rather than benzyl bromide and compound 22 rather than compound 3. After column chromatography, 168 mg (81.3% yield) of compound 23 was isolated in a purity of >99% as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09315514B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-8e18626d19394d378c069907dddc732d |
| Source note | uspto-grants-2016_04 |