Sulfuric Acid → 5-(2-Azabicyclo[2.2.2]oct-5-en-5-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	Sulfuric Acid	HCID 1118	—
반응물	Acetonitrile	HCID 6342	—
반응물	Metaperiodic acid	HCID 65185	—
반응물	1-(2,2-Dimethylpropyl)-5-[2-(4-methoxyphenyl)-2-azabicyclo[2.2.2]oct-5-en-5-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one	HCID 117702496	—
용매	Water	HCID 962	—
생성물	5-(2-Azabicyclo[2.2.2]oct-5-en-5-yl)-1-(2,2-dimethylpropyl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one	HCID 71135233	—

반응 조건

온도	50 °C

반응 단계

1-(2,2-Dimethylpropyl)-5-[2-(4-methoxyphenyl)-2-azabicyclo[2.2.2]oct-5-en-5-yl]-3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (2-4, 339 mg, 0.78 mmol, 1.0 equiv) was added to CH3CN (7 mL) and water (7 mL) To this suspension was added aqueous H2SO4 (0.78 mL, 0.78 mmol, 1.0 equiv, 1.0 M) followed by periodic acid in one portion (179 mg, 0.78 mmol, 1.0 equiv). The reaction contents were heated to 50° C. for 18 h. Following this duration,

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09315518B2
출처 데이터셋	uspto-grants-2016_04
ORD ID	ord-97c6c2e867d64a98a8516bd6bbde74bd
출처 메모	uspto-grants-2016_04