2-(Bromomethyl)pyridine hydrobromide → HCID 178429435, compound

HRID 629958Notes

Reaction equation

HRID 629958 reaction equation
Br.Br[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[CH3:10][C:11]1[N:16]=[C:15]([SH:17])[N:14]=[C:13]([OH:18])[CH:12]=1>>[CH3:10][C:11]1[N:16]=[C:15]([S:17][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[N:14]=[C:13]([OH:18])[CH:12]=1

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178429541HCID 178429541, compound

Product 1

HCID 178429435HCID 178429435, compoundYield 86%

Procedure

As per procedure from Example 1, 2-(bromomethyl)pyridine hydrobromide and 6-methyl-2-sulfanylpyrimidin-4-ol were combined to provide the title compound as a white solid (86% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.68 (s, 3H), 4.47 (s, 2H), 6.00 (s, 1H), 7.25 (dd, 1H), 7.47 (d, 1H), 7.72 (dd, 1H), 8.50 (d, 1H); M+234.

Sources & evidence

ORD record
ord-943a3fcf0c6342ed9c98c4973e0e1ee1
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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