Triethylamine → 2-[(3-chloro-1-benzothiophen-2-yl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-one

HRID 629979Notes

Reaction equation

HRID 629979 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([SH:8])[N:5]=[C:4]([OH:9])[CH:3]=1.C(N(CC)CC)C.Br[CH2:18][C:19]1[S:20][C:21]2[CH:28]=[CH:27][CH:26]=[CH:25][C:22]=2[C:23]=1[Cl:24]>C(O)C>[Cl:24][C:23]1[C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[S:20][C:19]=1[CH2:18][S:8][C:6]1[N:5]=[C:4]([OH:9])[CH:3]=[C:2]([CH3:1])[N:7]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 8167082-(Bromomethyl)-3-chloro-1-benzothiopheneHCID 178429541HCID 178429541, compound

Product 1

HCID 1784295302-[(3-chloro-1-benzothiophen-2-yl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-oneYield 60.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-methyl-2-sulfanylpyrimidin-4-ol (148 mg, 1.0 mmol) was dissolved in absolute ethanol (8 mL), then triethylamine (180 μL, 1.3 mmol) and 2-(bromomethyl)-3-chloro-1-benzothiophene (300 mg, 1.2 mmol) were added. The mixture was stirred overnight at room temperature. The precipitate was filtered, washed with ethanol and water and then diethyl ether, and dried in vacuo to afford to 2-{[(3-chloro-1-benzothiophen-2-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (195 mg, 58% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.27 (s, 3H), 4.72 (s, 2H), 5.69 (s, 1H), 6.07 (bs, 1H), 7.43-7.53 (m, 2H), 7.73-7.76 (m, 1H), 7.97-8.00 (m, 1H), 12.29 (bs, 1H); LRMS (ES+) m/z 323 (100%, M+1), 325 (35%, M+3).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ethanol and water
  3. dry with materialdiethyl ether, and dried in vacuo

Sources & evidence

ORD record
ord-31694678d6434ded9ade8631a988d2bf
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Reaction notes

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