反应详情

2-{[(3-chloropyridin-4-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (100 mg, 373 μmol) was stirred in methanol (10 mL) and a solution of 4 N HCl in dioxane (140 μL, 560 mmol) was added dropwise at 0° C. The mixture was stirred for 1.5 hours at room temperature. The solvent was removed, and the residue was washed 3 times with diethyl ether and dried in vacuo to afford to 2-{[(3-chloropyridin-4-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride (103 mg, 91% yield); 1H NMR (400 MHz, DMSO-d6): δ 2.19 (s, 3H), 4.48 (s, 2H), 6.07 (bs, 1H), 7.76 (d, J=5.1 Hz, 1H), 8.53 (d, J=5.1 Hz, 1H), 8.74 (s, 1H); LRMS (ES+) m/z 268 (100%, M+1), 270 (65%, M+3).

1. customThe solvent was removed
2. washthe residue was washed 3 times with diethyl ether
3. customdried in vacuo